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Advanced filters: Author: Iaroslav Kosov Clear advanced filters

  • The UbiD family of reversible decarboxylases interconvert propenoic or aromatic acids with the corresponding alkenes or aromatic compounds, using a transient 1,3-dipolar cycloaddition between the substrate and the prenylated flavin mononucleotide cofactor. Atomic-resolution crystallography shows targeted destabilization of the intermediate covalent adducts, allowing the enzyme to harness 1,3-dipolar cycloaddition as a readily reversible reaction.

    • Samuel S. Bailey
    • Karl A. P. Payne
    • David Leys
    Research
    Nature Chemistry
    Volume: 11, P: 1049-1057