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Showing 1–12 of 12 results
Advanced filters: Author: Idan Yelin Clear advanced filters

  • The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs). Here, analyzing viral loads of BTIs post third vaccine shot, Levine-Tiefenbrun et al. show waning of the booster’s effectiveness in reducing infectiousness within months, mirroring the rate and magnitude of decline observed post the second shot.

    • Matan Levine-Tiefenbrun
    • Idan Yelin
    • Roy Kishony
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-4

  • Bacterial resistance to beta-lactam antibiotics is on the rise, but laboratory evolution studies do not always recapitulate clinical resistance levels. Here, the authors select Escherichia coli mutants with varying degrees of beta-lactam resistance, showing that combinations of distinct genetic mutations, accessible at large population sizes, can drive high-level resistance independently of beta-lactamases.

    • Rotem Gross
    • Idan Yelin
    • Roy Kishony
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Staphylococcus epidermidis is a widespread early colonizer in the neonatal skin and a cause of hospital-acquired infections. Here, using whole-genome sequencing of 632 cultured S. epidermidis isolates derived from premature infants, the authors characterize the spatiotemporally strain-level genomic variability, finding patient-specific colonization signatures and a fast gain and loss of the antibiotic resistance gene mecA via the evolution of genotypically diverse structural variants.

    • Manoshi S. Datta
    • Idan Yelin
    • Roy Kishony
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • New data from a large healthcare organization in Israel reveal a reduction in new infections in an unvaccinated population in communities with rapid vaccination rollouts, suggesting that mass vaccination strategies confer cross-protection of unvaccinated individuals.

    • Oren Milman
    • Idan Yelin
    • Roy Kishony
    Research
    Nature Medicine
    Volume: 27, P: 1367-1369

  • Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al. identify rare mutations in the ampC beta-lactamase gene that escape this adaptive tradeoff specifically for certain drug combinations.

    • Dor Russ
    • Fabian Glaser
    • Roy Kishony
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Antibiotic concentrations are low in most natural environments, except around localized antibiotic sources. Here, Chait et al.show that sub-inhibitory antibiotic levels can interact with many other stresses to generate complex patterns of selection for and against resistance to the antibiotic.

    • Remy Chait
    • Adam C. Palmer
    • Roy Kishony
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • On the basis of the personalized data of over 300,000 individuals with urinary tract infections, a machine-learning algorithm can help select an antibiotic for treatment of a urinary tract infection to which the infecting pathogen is not already resistant.

    • Idan Yelin
    • Olga Snitser
    • Roy Kishony
    Research
    Nature Medicine
    Volume: 25, P: 1143-1152

  • Roy Kishony and colleagues sequenced the genomes of Burkholderia dolosa isolates from patients with cystic fibrosis, using colony resequencing and deep population sequencing approaches to allow comparisons of multiple isolates from each individual. They identify extensive intrastrain genomic diversity and show specific signatures of selection acting on the pathogen within individual patients.

    • Tami D Lieberman
    • Kelly B Flett
    • Roy Kishony
    Research
    Nature Genetics
    Volume: 46, P: 82-87