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Showing 1–3 of 3 results
Advanced filters: Author: Idia V. Rodriguez Clear advanced filters

  • High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cells and a local type-I interferon response.

    • Shaheed A. Abdulhaqq
    • Melween Martinez
    • Luis J. Montaner
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Here, the authors show that the time elapsed between Zika infection and subsequent dengue virus infection affects the magnitude and durability of the antibody and cell-mediated immune responses against dengue virus, but not viremia. This research in non-human primates has implications for co-endemic regions and vaccination.

    • Erick X. Pérez-Guzmán
    • Petraleigh Pantoja
    • Carlos A. Sariol
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Antibodies against dengue virus (DENV) can increase Zika virus (ZIKV) infectionin vitro, but their role in vivoremains largely unknown. Here, the authors show that pre-existing immunity from a 2.8 years earlier DENV infection does not affect ZIKV pathogenesis in macaques but instead shortens Zika viremia.

    • Petraleigh Pantoja
    • Erick X. Pérez-Guzmán
    • Carlos A. Sariol
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13