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Showing 1–12 of 12 results
Advanced filters: Author: Ido Pen Clear advanced filters

  • Lung fibrosis development involves alveolar macrophages, with mechanisms that are incompletely understood. Here, the authors show that alveolar macrophages mediate the disassembly of pleuro-alveolar junctions, driving fibrosis via connective tissue transfer, and demonstrate that targeting this process can reverse chronic fibrosis in mice.

    • Adrian Fischer
    • Wei Han
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • In vertebrates, sex can be determined either genetically or by temperature, but the evolutionary causes of this variation remain unknown. These authors show how live-bearing lizards at different climatic extremes of their range differ in their sex-determining mechanisms, with temperature-dependent sex determination in the lowlands and genotypic sex determination at higher altitudes. Their results establish an adaptive explanation for intra-specific divergence in sex-determining systems driven by phenotypic plasticity and ecological selection.

    • Ido Pen
    • Tobias Uller
    • Erik Wapstra
    Research
    Nature
    Volume: 468, P: 436-438

  • The authors show that depletion of pro-apoptotic Bax protein bestows hair follicle stem cells with the capacity to eliminate viable neighboring cells by sequestration of TNFα, resulting in an increased stem cell pool, accelerated wound repair and de novo hair follicle regeneration.

    • Marianna Yusupova
    • Roi Ankawa
    • Yaron Fuchs
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglycemia and hepatic steatosis in response to GCs.

    • M. Charlotte Hemmer
    • Michael Wierer
    • N. Henriette Uhlenhaut
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • This protocol describes a reproducible and reliable method for excisional skin wound healing assays in mice. The use of lineage-tracing assays to investigate the contribution of different cell populations to the repair process is also discussed.

    • Matan Yampolsky
    • Ido Bachelet
    • Yaron Fuchs
    Protocols
    Nature Protocols
    Volume: 19, P: 184-206