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Showing 1–5 of 5 results
Advanced filters: Author: Ignacio Heras-Murillo Clear advanced filters

  • Long-term metastatic relapse is observed in patients with luminal breast cancer (BC). Here, the authors show that fatty acid amide hydrolase is a tumour suppressor for lung metastasis in mouse models of BC and a predictor of metastasis in patients with luminal BC.

    • Isabel Tundidor
    • Marta Seijo-Vila
    • Eduardo Pérez-Gómez
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.

    • Emilia Mira
    • Lorena Carmona-Rodríguez
    • Santos Mañes
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • Dendritic cells (DCs) are antigen-presenting cells that function at the interface between innate and adaptive immunity, thereby acting as key mediators of antitumour immune responses and immunotherapy efficacy. In this Review, the authors outline the emerging complexity of intratumoural DC states that is being revealed through single-cell analyses as well as the contributions of different DC subsets to anticancer immunity and the activity of immune-checkpoint inhibitors. The authors also discuss advances in the development of DC-based cancer therapies and considerations for their potential combination with other anticancer therapies.

    • Ignacio Heras-Murillo
    • Irene Adán-Barrientos
    • David Sancho
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 21, P: 257-277