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Showing 1–3 of 3 results

Advanced filters: Author: Ignacio Torrecilla Clear advanced filters

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.

Swagata Halder
Ignacio Torrecilla
Kristijan Ramadan
ResearchOpen Access17 Jul 2019
Nature Communications

Volume: 10, P: 1-18
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.

John Fielden
Katherine Wiseman
Kristijan Ramadan
ResearchOpen Access09 Mar 2020
Nature Communications

Volume: 11, P: 1-16
SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

Juri Na
Joseph A. Newman
Anne E. Kiltie
ResearchOpen Access08 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-17