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Showing 1–8 of 8 results
Advanced filters: Author: Ignasi Roig Clear advanced filters

  • ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

    • Sarai Pacheco
    • Andros Maldonado-Linares
    • Ignasi Roig
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • CEP63 is a centrosomal protein that is mutated in the microcephaly disease Seckel syndrome. Here the authors disrupt Cep63 in the mouse and find that neural progenitor cells undergo p53-dependent cell death, and uncover a role for CEP63 in ensuring correct meiotic recombination in male gametes.

    • Marko Marjanović
    • Carlos Sánchez-Huertas
    • Travis H. Stracker
    Research
    Nature Communications
    Volume: 6, P: 1-14

  • ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

    • Alexander Widger
    • Shantha K. Mahadevaiah
    • James M.A. Turner
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Homologous recombination ensures genome integrity during meiotic recombination. Here the authors reveal that factors SWS1 and SWSAP1 are critical for meiotic homologues recombination, particularly in promoting assembly of RAD51 and DMC1 on early recombination intermediates.

    • Carla M. Abreu
    • Rohit Prakash
    • Maria Jasin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Meiotic recombination involves the generation of double-strand breaks, that needs to be carefully controlled to avoid fetal aneuploidy. In worms and yeast, crossover numbers are constant regardless of the amount of double-strand breaks. Jasin and colleagues now show that such crossover homeostasis mechanisms exist at two stages in mammalian meiosis.

    • Francesca Cole
    • Liisa Kauppi
    • Maria Jasin
    Research
    Nature Cell Biology
    Volume: 14, P: 424-430