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Showing 1–17 of 17 results
Advanced filters: Author: Igor Antoshechkin Clear advanced filters

  • An improved, fully re-annotated Aedes aegypti genome assembly (AaegL5) provides insights into the sex-determining M locus, chemosensory systems that help mosquitoes to hunt humans and loci involved in insecticide resistance and will help to generate intervention strategies to fight this deadly disease vector.

    • Benjamin J. Matthews
    • Olga Dudchenko
    • Leslie B. Vosshall
    ResearchOpen Access
    Nature
    Volume: 563, P: 501-507

  • The popularity ofCaenorhabditis elegans as a model organism is paralleled by the range of resources that are available to worm researchers. This Review provides a guide to existing C. elegansresources, and highlights areas for future development.

    • Igor Antoshechkin
    • Paul W. Sternberg
    Reviews
    Nature Reviews Genetics
    Volume: 8, P: 518-532

  • Gene drive elements spread linked traits and can be used to change the composition or fate of populations. Here Oberhofer and colleagues engineer gene drive in the plant Arabidopsis thaliana. Applications include genetic biocontrol and conservation.

    • Georg Oberhofer
    • Michelle L. Johnson
    • Bruce A. Hay
    Research
    Nature Plants
    Volume: 10, P: 936-953

  • This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

    • Ian Dunham
    • Anshul Kundaje
    • Ewan Birney
    ResearchOpen Access
    Nature
    Volume: 489, P: 57-74

  • A description is given of the ENCODE effort to provide a complete catalogue of primary and processed RNAs found either in specific subcellular compartments or throughout the cell, revealing that three-quarters of the human genome can be transcribed, and providing a wealth of information on the range and levels of expression, localization, processing fates and modifications of known and previously unannotated RNAs.

    • Sarah Djebali
    • Carrie A. Davis
    • Thomas R. Gingeras
    ResearchOpen Access
    Nature
    Volume: 489, P: 101-108

  • A. aegypti is the principal vector for arboviruses that impact on human health and wellbeing. Here the authors use precision guided sterile insect technique—pgSIT—to suppress or eliminate mosquito populations in multigeneration cage experiments.

    • Ming Li
    • Ting Yang
    • Omar S. Akbari
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • In most species, sex is determined by genetic or environmental factors. Here, the authors present evidence that sex determination in Bursaphelenchus nematodes is instead likely to be regulated by a random, epigenetic mechanism.

    • Ryoji Shinya
    • Simo Sun
    • Paul W. Sternberg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • CRISPR-based engineering can be used to bias sex ratios. Here the authors develop a transgenic line of Drosophila melanogaster expressing Cas9 from the Y chromosome and functionally characterize the utility of this strain for both sex selection and gene drive.

    • Stephanie Gamez
    • Duverney Chaverra-Rodriguez
    • Omar S. Akbari
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The recovery of two circularized genomes of the Heimdallarchaeum species from hydrothermal vent enrichment cultures reveals that these Asgard archaea carry diverse mobile genetic elements, such as an integrative viral genome and aloposons. These mobile genetic elements contain several bacteria- and phage-derived genes, modulating the shuffling of information between bacteria and archaea, and potentially influencing eukaryogenesis.

    • Fabai Wu
    • Daan R. Speth
    • Victoria J. Orphan
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 200-212

  • The Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types; these data were compared with those from human to confirm substantial conservation in the newly annotated potential functional sequences and to reveal pronounced divergence of other sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization.

    • Feng Yue
    • Yong Cheng
    • Bing Ren
    ResearchOpen Access
    Nature
    Volume: 515, P: 355-364

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • Erich Schwarz and colleagues report whole-genome sequencing of the zoonotic hookworm Ancylostoma ceylanicum. They also analyze the transcriptome through the course of infection in golden hamsters and identify groups of genes showing differential regulation across different stages.

    • Erich M Schwarz
    • Yan Hu
    • Raffi V Aroian
    ResearchOpen Access
    Nature Genetics
    Volume: 47, P: 416-422

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698