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Showing 1–10 of 10 results
Advanced filters: Author: Igor B. Zhulin Clear advanced filters

  • Purines control intracellular energy homeostasis and nucleotide synthesis, and act as signaling molecules. Here, the authors combine structural and sequence information to define a purine-binding motif that is present in sensor domains of thousands of bacterial receptors that modulate motility, gene expression, metabolism, and second-messenger turnover.

    • Elizabet Monteagudo-Cascales
    • Vadim M. Gumerov
    • Tino Krell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • “Out of one, many”. The authors show that, despite binding to a common network of genes, two transcription factors each have their own set of direct targets (also known as their ‘regulon’). Thus, out of one bound network, many regulons are possible.

    • Ashton S. Holub
    • Sarah G. Choudury
    • Aman Y. Husbands
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Pollen apertures, the special areas on the surfaces of pollen grains that allow pollen tube emergence, show enormous diversity of patterns across plant species. Now a species-specific module formed by two DOG1-domain proteins is identified to control the formation of pollen apertures in flowering plants.

    • Byung Ha Lee
    • Rui Wang
    • Anna A. Dobritsa
    Research
    Nature Plants
    Volume: 7, P: 966-978

  • Bacterial chemoreceptors regulate the kinase CheA via ligand-induced conformational changes. Using long molecular dynamics simulations, Ortega et al.show that these changes are associated with flipping of the stacked aromatic rings of highly conserved phenylalanine residues within the kinase-activating domain.

    • Davi R. Ortega
    • Chen Yang
    • Igor B. Zhulin
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to corresponding PheWAS in human.

    • Xusheng Wang
    • Ashutosh K. Pandey
    • Robert W. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • The shewanellae are masters of metabolism and can catabolize numerous carbon sources either aerobically or anaerobically using a range of electron acceptors. Ubiquitous among microbial communities from marine to soil environments, this genus is important in carbon cycling and bioremediation. Systems-biology approaches could shed new light on the ecophysiology of these bacteria.

    • James K. Fredrickson
    • Margaret F. Romine
    • James M. Tiedje
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 592-603

  • The evolution of monoderm and diderm cell envelopes, and thus of Gram-positive and Gram-negative bacteria, is a long-standing question. In this Opinion article, Tocheva, Ortega and Jensen propose, based on recent electron cryotomography data, a new model that places sporulation at the heart of bacterial evolution.

    • Elitza I. Tocheva
    • Davi R. Ortega
    • Grant J. Jensen
    Reviews
    Nature Reviews Microbiology
    Volume: 14, P: 535-542