Nature Search

Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection

T-cell–mediated rejection (TCMR) remains a major cause of kidney transplant failure with incompletely understood mechanisms. Here the authors use single-nucleus RNA sequencing, spatial transcriptomics and immunofluorescence to show that injured kidney epithelial cell states associate with poor transplant outcomes after T-cell–mediated rejection.

Anna Maria Pfefferkorn
Lorenz Jahn
Christian Hinze
ResearchOpen Access28 Jan 2026
Nature Communications

Volume: 17, P: 1-19
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB

Igor Levchenko
Robert A Grant
Tania A Baker
Research08 May 2005
Nature Structural & Molecular Biology

Volume: 12, P: 520-525
Liver support strategies: cutting-edge technologies

This Review describes advances in artificial and bioartificial liver support systems and current developments. The evolving field of hepatocyte transplantation as a less invasive alternative to whole-organ transplantation is also reviewed, and a detailed overview of cutting-edge hepatic tissue engineering is included. Challenges and opportunities of the different approaches are analysed with respect to clinical relevance, as well as basic science concerns.

Benjamin Struecker
Nathanael Raschzok
Igor M. Sauer
Reviews29 Oct 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 11, P: 166-176
HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins

RNA binding protein HDLBP (or Vigilin) localizes in the endoplasmic reticulum (ER) membrane. Here the authors show that HDLBP contributes to translation of ER-targeted mRNAs.

Ulrike Zinnall
Miha Milek
Markus Landthaler
ResearchOpen Access18 May 2022
Nature Communications

Volume: 13, P: 1-21
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4⁺ memory T cells

Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.

Kim-Long Truong
Stephan Schlickeiser
Birgit Sawitzki
ResearchOpen Access22 May 2019
Nature Communications

Volume: 10, P: 1-15
Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

ATP-dependent chromatin remodelers are often found mutated in human cancers. Here, the authors characterize the nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2.

Kristina Kovač
Anja Sauer
Alexander Brehm
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-13
Extracellular NAD⁺ response to post-hepatectomy liver failure: bridging preclinical and clinical findings

An analysis on liver disease patients suggests that extracellular Nicotinamide adenine dinucleotide (eNAD ⁺) correlates with liver fibrosis and post-hepatectomy liver failure, with NAD⁺ administration improving survival and liver regeneration in mice and hepatocyte viability in vitro.

Can Kamali
Philipp Brunnbauer
Felix Krenzien
ResearchOpen Access14 Aug 2024
Communications Biology

Volume: 7, P: 1-13
Single versus tandem autologous stem cell transplantation in newly diagnosed multiple myeloma

Nora Grieb
Alexander Oeser
Maximilian Merz
ResearchOpen Access05 Dec 2024
Bone Marrow Transplantation

Volume: 60, P: 335-345
The nanomolar sensing of nicotinamide adenine dinucleotide in human plasma using a cycling assay in albumin modified simulated body fluids

Philipp Brunnbauer
Annekatrin Leder
Felix Krenzien
ResearchOpen Access31 Oct 2018
Scientific Reports

Volume: 8, P: 1-15
Reduced Cortical Thickness is Associated with the Glutamatergic Regulatory Gene Risk Variant DAOA Arg30Lys in Schizophrenia

C Christoph Schultz
Igor Nenadic
Ralf G M Schlösser
Research20 Apr 2011
Neuropsychopharmacology

Volume: 36, P: 1747-1753
Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age

Elias K. Mai
Kaya Miah
Hartmut Goldschmidt
ResearchOpen Access20 Jul 2020
Leukemia

Volume: 35, P: 809-822
The evolution of polymorphism in the warning coloration of the Amazonian poison frog Adelphobates galactonotus

Diana Rojas
Albertina P. Lima
Adam Stow
Research11 Nov 2019
Heredity

Volume: 124, P: 439-456
Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans

H. Napierala
K.-H. Hillebrandt
B. Struecker
ResearchOpen Access02 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Cystic transformation of focal lesions after therapy is associated with remission but adverse outcome in myeloma

Maximilian Merz
Thomas Hielscher
Jens Hillengass
CorrespondenceOpen Access27 Aug 2019
Blood Cancer Journal

Volume: 9, P: 1-5
Density functional theory-based electric field gradient database

Kamal Choudhary
Jaafar N. Ansari
Karen L. Sauer
ResearchOpen Access21 Oct 2020
Scientific Data

Volume: 7, P: 1-10
Composite tissue allotransplantation: opportunities and challenges

Jasper Iske
Yeqi Nian
Stefan G. Tullius
Reviews06 Mar 2019
Cellular & Molecular Immunology

Volume: 16, P: 343-349

Search

Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection

Versatile modes of peptide recognition by the AAA+ adaptor protein SspB

Liver support strategies: cutting-edge technologies

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins

Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4⁺ memory T cells

Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

Extracellular NAD⁺ response to post-hepatectomy liver failure: bridging preclinical and clinical findings

Single versus tandem autologous stem cell transplantation in newly diagnosed multiple myeloma

The nanomolar sensing of nicotinamide adenine dinucleotide in human plasma using a cycling assay in albumin modified simulated body fluids

Reduced Cortical Thickness is Associated with the Glutamatergic Regulatory Gene Risk Variant DAOA Arg30Lys in Schizophrenia

Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age

The evolution of polymorphism in the warning coloration of the Amazonian poison frog Adelphobates galactonotus

Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans

Cystic transformation of focal lesions after therapy is associated with remission but adverse outcome in myeloma

Density functional theory-based electric field gradient database

Composite tissue allotransplantation: opportunities and challenges

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