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Advanced filters: Author: Ikuko Omori Clear advanced filters

Systematic identification of intron retention associated variants from massive publicly available transcriptome sequencing data

This paper proposed a novel in-silico framework for automatically screening disease-related variants and applied it to over 200,000 transcriptomes, providing an example to acquire medically relevant knowledge from publicly available sequence data.

Yuichi Shiraishi
Ai Okada
Akihide Yoshimi
ResearchOpen Access29 Sept 2022
Nature Communications

Volume: 13, P: 1-13
Structural basis of cytokine-mediated activation of ALK family receptors

Structural studies of the complex of anaplastic lymphoma kinase and leukocyte tyrosine kinase and their activating cytokines identify unique architectural features of the complex, and provide a novel mechanistic paradigm among receptor tyrosine kinases.

Steven De Munck
Mathias Provost
Savvas N. Savvides
Research13 Oct 2021
Nature

Volume: 600, P: 143-147
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

Beclin 1 is an essential mediator of mammalian autophagy that has anti-tumour activity. Beclin 1 associates with Atg14L and Rubicon to regulate autophagosome formation and maturation, respectively.

Kohichi Matsunaga
Tatsuya Saitoh
Tamotsu Yoshimori
Research08 Mar 2009
Nature Cell Biology

Volume: 11, P: 385-396