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Showing 1–5 of 5 results
Advanced filters: Author: Ikuo Ogiwara Clear advanced filters

  • The authors report a new type of genetic alteration in lung adenocarcinoma. Fusions of KIF5B with RET kinase are found in 1–2% of lung cancer patients, segregate from other known alterations and can potentially be targeted using RET kinase inhibitors.

    • Takashi Kohno
    • Hitoshi Ichikawa
    • Tatsuhiro Shibata
    Research
    Nature Medicine
    Volume: 18, P: 375-377

  • Ikuo Ogiwara et al. find that nonsense mutations in the gene coding for the voltage-gated sodium channel Nav1.2, SCN2A, cause absence-like seizures in mice. They also find that Nav1.2 haplodeficiency in excitatory, but not in inhibitory, neurons contributes to epileptogenesis.

    • Ikuo Ogiwara
    • Hiroyuki Miyamoto
    • Kazuhiro Yamakawa
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-16

  • Voltage-gated Na+ channel β-subunits are concentrated in the nodes of Ranvier and axon initial segments of myelinated axons and have a variety of functions. Here the authors show, using genetically modified mice, that this subunit is present in unmyelinated fibres in the striatum and is required for generation of resurgent Na+ current in striatal neurons.

    • Haruko Miyazaki
    • Fumitaka Oyama
    • Nobuyuki Nukina
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.

    • Hiroyuki Miyamoto
    • Tetsuya Tatsukawa
    • Kazuhiro Yamakawa
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13