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Showing 1–2 of 2 results
Advanced filters: Author: Ila Marathe Clear advanced filters

  • The Gabija system constitutes one of the most prevalent anti-phage defense systems and is composed of GajA and GajB. Here, using cryo-EM and biochemistry, the authors show that GajA and GajB form a supramolecular complex with a stoichiometry of 4:4 to promote anti-phage defense.

    • Xiao-Yuan Yang
    • Zhangfei Shen
    • Tian-Min Fu
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1243-1250

  • Using cryo-electron microscopy the authors show that PtuA, an ATPase, and PtuB, a nuclease, assemble into a supramolecular complex with a stoichiometry of 6:2 for anti-phage defense in bacteria. Nucleoside triphosphates inhibit PtuAB activity while phage infection activates PtuAB to cleave phage genome for immune defense.

    • Yuanyuan Li
    • Zhangfei Shen
    • Yamei Yu
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 413-423