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Showing 1–6 of 6 results
Advanced filters: Author: Ilia Platzman Clear advanced filters

  • Staufer et al. provide a protocol for preparation of synthetic minimal virions (MiniV) of SARS-CoV-2, mimicking viral structure and allowing for precise investigation of receptor binding mechanism. They find that the highly conserved free fatty acid binding pocket (FABP) can function as an allosteric regulator, enabling adaptation of immunogenicity via binding of proinflammatory free fatty acids and mediating the spike open to-closed equilibrium.

    • Oskar Staufer
    • Kapil Gupta
    • Joachim P. Spatz
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.

    • Omer Adir
    • Mia R. Albalak
    • Avi Schroeder
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Controlled actuation is an important aspect of synthetic cellular systems. Here, the authors combine pH responsive DNA origami structures with light triggered proton pump engineered E. coli to trigger a change in pH and control the deformation of giant unilamellar vesicles by simple illumination.

    • Kevin Jahnke
    • Noah Ritzmann
    • Kerstin Göpfrich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • The formation of cellular adhesion complexes is important in normal and pathological cell activity, and is determined by the force imposed by the combined effect of the distribution of extracellular matrix molecules and substrate rigidity.

    • Roger Oria
    • Tina Wiegand
    • Pere Roca-Cusachs
    Research
    Nature
    Volume: 552, P: 219-224

  • Synthetic biology encompasses engineering approaches to either redesign biological organisms with new molecular abilities or build up organism from the bottom to improve our understanding of life. Here, the authors summarize current approaches that can be applied for the synthetic engineering of viral replication cycles and discuss the potential DURC risk associated with such bottom-up approaches in infectious disease.

    • Oskar Staufer
    • Gösta Gantner
    • Joachim P. Spatz
    ReviewsOpen Access
    Nature Communications
    Volume: 13, P: 1-10