The challenge of predicting potential efficacy of anti-atherosclerotic drugs before the completion of long-term trials with endpoints such as mortality has stimulated efforts to develop intermediate measures of efficacy. Nissen and colleagues describe how intravascular ultrasound can be applied to the serial assessment of atheroma burden in response to treatment, which has resulted in its emergence as a key technology in the evaluation and approval of novel drugs.
- Stephen J. Nicholls
- Ilke Sipahi
- Steven E. Nissen
