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Showing 1–3 of 3 results
Advanced filters: Author: Ilona C. Grunwald Kadow Clear advanced filters

  • Identification of two CO2 receptors in Drosophila antennae, Gr21a and Gr63a, determines that their co-expression is necessary and sufficient for CO2 sensing. Flies lacking one of the two are insensitive to CO2, and confer CO2 responsivity when both receptors are expressed in heterologous neurons.

    • Walton D. Jones
    • Pelin Cayirlioglu
    • Leslie B. Vosshall
    Research
    Nature
    Volume: 445, P: 86-90

  • Hypothalamic melanocortin neurons control energy homoeostasis by modulating appetite. Here, the authors reveal a role for the transcription factor Tbx3 as a regulator of the peptidergic identity and function of immature and mature mouse melanocortin neurons.

    • Carmelo Quarta
    • Alexandre Fisette
    • Matthias H. Tschöp
    Research
    Nature Metabolism
    Volume: 1, P: 222-235

  • Designing optogenetically functionalized G protein-coupled receptors (optoXRs) to mimic endogenous signaling in vivo is challenging. Here, the authors optimize the design of optoXRs by considering evolutionary conserved protein interactions, and they employ this approach in fruit flies.

    • Fangmin Zhou
    • Alexandra-Madelaine Tichy
    • Peter Soba
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18