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Showing 1–6 of 6 results
Advanced filters: Author: Ilse Vanhorebeek Clear advanced filters

  • Alterations in the hypothalamic–pituitary–adrenal axis play an important part in survival of critically ill patients. The usefulness of currently available therapeutic interventions designed to correct these alterations is, however, unclear. This Review explains the response to stress in critically ill patients and discusses issues surrounding terminology and the role of glucocorticoids in therapy.

    • Dieter Mesotten
    • Ilse Vanhorebeek
    • Greet Van den Berghe
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 4, P: 496-505

  • Hyperglycemia often occurs in patients who are acutely ill. This Review details the findings of several recent studies showing that using insulin to maintain normoglycemia for a few days significantly improved survival and morbidity in patients in medical or surgical intensive care units.

    • Lies Langouche
    • Ilse Vanhorebeek
    • Greet Van den Berghe
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 3, P: 270-278

  • Neuroendocrine responses differ markedly in chronic critical illness compared with acute illness, and the chronic response may be harmful. Hyperglycemia is a major risk factor, and control of blood glucose is important. Because hypothalamic–pituitary axes interact during chronic illness, validating new therapies aimed at correcting multiple endocrine pathways seems warranted.

    • Ilse Vanhorebeek
    • Lies Langouche
    • Greet Van den Berghe
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 2, P: 20-31