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Showing 1–9 of 9 results
Advanced filters: Author: Ilya M. Flyamer Clear advanced filters

  • Genomes are partitioned into topologically associating domains (TADs). Here the authors present single-nucleus Hi-C maps in Drosophila at 10 kb resolution, demonstrating the presence of chromatin compartments in individual nuclei, and partitioning of the genome into non-hierarchical TADs at the scale of 100 kb, which resembles population TAD profiles.

    • Sergey V. Ulianov
    • Vlada V. Zakharova
    • Sergey V. Razin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two aspects of nuclear function.

    • Stefano Gnan
    • Ilya M. Flyamer
    • Sara C. B. Buonomo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Systematic deletions of individual imitation switch (ISWI) subunits in mouse embryonic stem cell lines highlight the role of BPTF in regulating chromatin accessibility at most CTCF sites and binding at a subset, with a modest effect on its insulating function.

    • Mario Iurlaro
    • Francesca Masoni
    • Dirk Schübeler
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1203-1212

  • Single-nucleus Hi-C of embryos, polymer simulations and single-molecule imaging collectively reveal that MCM complexes influence genome folding and gene expression by impeding DNA loop extrusion.

    • Bart J. H. Dequeker
    • Matthias J. Scherr
    • Kikuë Tachibana
    ResearchOpen Access
    Nature
    Volume: 606, P: 197-203

  • The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.

    • Sergey V. Ulianov
    • Semen A. Doronin
    • Yuri Y. Shevelyov
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Kane et al. show that cohesin is required for long-range, but not shorter-range, enhancer function at the Shh locus, implicating loop extrusion as a mechanism for keeping enhancer and target genes sufficiently close together for effective enhancer–promoter communication.

    • Lauren Kane
    • Iain Williamson
    • Wendy A. Bickmore
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 891-897