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Showing 1–14 of 14 results
Advanced filters: Author: Ilya Shamovsky Clear advanced filters

  • An ultra-high-resolution chromatin organization map of E. coli, using Micro-C, reveals intricate chromatin structures involved in the silencing of horizontally transferred genes and those associated with active operons.

    • Alexey A. Gavrilov
    • Ilya Shamovsky
    • Evgeny Nudler
    ResearchOpen Access
    Nature
    Volume: 645, P: 1060-1070

  • A collection of RNA polymerase mutants spanning all possible substitutions of the rifampicin binding site is generated and characterized, increasing our understanding of antibiotic mechanisms and bacterial physiology.

    • Kevin B. Yang
    • Maria Cameranesi
    • Evgeny Nudler
    ResearchOpen Access
    Nature
    Volume: 622, P: 180-187

  • Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

    • Alan Varghese
    • Ivan Gusarov
    • Evgeny Nudler
    ResearchOpen Access
    Nature
    Volume: 643, P: 776-784

  • Here, using proteomics, next-generation sequencing, biochemistry and cryo-EM, the authors delineate the role of CedA as an unconventional transcription factor in Escherichia coli, which protects from different stressors, including antibiotics, by regulating the transcriptional landscape.

    • Nikita Vasilyev
    • Mengjie M. J. Liu
    • Evgeny Nudler
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 141-149

  • Hydrogen sulfide (H2S) production in Escherichia coli is controlled by the sulfurtransferase 3MST. Here, the authors describe an alternative mechanism for H2S biosynthesis via activation of the thiosulfate sulfurtransferase PspE, a process mediated by the transcription factor YcjW.

    • Lyly Luhachack
    • Aviram Rasouly
    • Evgeny Nudler
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • Glycogen is a storage form of glucose in cells. Here, Gusarovet al. show that glycogen-derived glucose can be used to quickly regenerate the antioxidant glutathione and that inhibiting glycogen synthesis extends C. eleganslifespan, whereas glycogen accumulation drives organismal ageing in worms.

    • Ivan Gusarov
    • Bibhusita Pani
    • Evgeny Nudler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Reactive oxygen species are required for the long lifespan, and glutathione is an antioxidant. Here the authors show that limiting the consumption of dietary thiols, including those naturally derived from the microbiota, increases proteotoxic stress resistance in worms and human cells, and extends C. elegans lifespan.

    • Ivan Gusarov
    • Ilya Shamovsky
    • Evgeny Nudler
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Maximum-depth sequencing (MDS), a new method of detecting extremely rare variants within a bacterial population, is used to show that mutation rates in Escherichia coli vary across the genome by at least an order of magnitude, and also to uncover mechanisms of antibiotic-induced mutagenesis.

    • Justin Jee
    • Aviram Rasouly
    • Evgeny Nudler
    Research
    Nature
    Volume: 534, P: 693-696