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Showing 1–9 of 9 results
Advanced filters: Author: Immanuel Kwok Clear advanced filters

  • Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

    • Daniela Cerezo-Wallis
    • Andrea Rubio-Ponce
    • Iván Ballesteros
    ResearchOpen Access
    Nature
    Volume: 649, P: 1003-1012

  • COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.

    • Guillaume Carissimo
    • Weili Xu
    • Lisa FP Ng
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

    • Tommaso Vicanolo
    • Alaz Özcan
    • Andrés Hidalgo
    Research
    Nature
    Volume: 641, P: 740-748

  • SpatialGlue is a graph neural network-based approach for integrating multimodal spatial omics data. Combining complementary data modalities improves the discovery of spatial domains as well as the identification of cell subpopulations across tissues.

    • Yahui Long
    • Kok Siong Ang
    • Jinmiao Chen
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1658-1667

  • Eosinophils are innate immune cells critical for protection from parasites, but their developmental origin remains under studied. Here they analyze development of eosinophils in zebrafish and find that eosinophilic lineage commitment and differentiation are regulated by the Cebp1-Cebpβ axis.

    • Gaofei Li
    • Yicong Sun
    • Yiyue Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Recent studies suggest that neutrophils can exhibit substantial function diversity. Here, Ostuni and colleagues perform immunophenotyping and transcriptome analysis to characterize the heterogeneity of human neutrophils, both under steady state and upon stress-induced conditions.

    • Elisa Montaldo
    • Eleonora Lusito
    • Renato Ostuni
    Research
    Nature Immunology
    Volume: 23, P: 1470-1483

  • Yingrou Tan et al. present a method streamlining surface creation in 3D imaging by applying the hue-saturation-brightness transformed channels simultaneously. They show the utility of this approach by imaging ear skin following needlestick injury, observing immune cell infiltration.

    • Yingrou Tan
    • Jackson Liang Yao Li
    • Lai Guan Ng
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-11