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  • MIPS521, a positive allosteric modulator of the adenosine A1 receptor, has analgesic properties in a rat model of neuropathic pain through a mechanism by which MIPS521 stabilizes the complex between adenosine, receptor and G protein.

    • Christopher J. Draper-Joyce
    • Rebecca Bhola
    • Arthur Christopoulos
    Research
    Nature
    Volume: 597, P: 571-576