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Showing 1–3 of 3 results
Advanced filters: Author: Ines Pramme-Steinwachs Clear advanced filters

  • Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocyte population that is enriched in adolescent subcutaneous fat and demonstrate that loss of Asc-1 triggers spontaneous beige adipocyte differentiation.

    • Lisa Suwandhi
    • Irem Altun
    • Siegfried Ussar
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates brown adipose tissue function through modifying ATF2 genomic binding and subsequent Ucp1 and Pgc-1α induction.

    • Katrin Fischer
    • Anna Fenzl
    • Timo D. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13