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Showing 1–7 of 7 results
Advanced filters: Author: Ines Sturmlechner Clear advanced filters

  • Homeostasis of memory T cells is modulated by each antigen encounter, thereby creating a heterogeneous population preventing precise tracking. Here, the authors use barcode-assisted tracing of Epstein-Barr virus-specific CD8+ memory T cells of young and older individuals to find antigen-guided, clonally divergent aging trajectories.

    • Ines Sturmlechner
    • Abhinav Jain
    • Jörg J. Goronzy
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple mechanisms, including inhibitory mechanisms that involve p53 binding to ribonucleases.

    • Ines Sturmlechner
    • Chance C. Sine
    • Jan M. van Deursen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Chronic inflammation is a sign of immune system aging. Here the authors show that T cells from older adults contribute to inflammation due to CISH-mediated enhanced proteasomal degradation of a component of the proton pump V-ATPase, resulting in reduced lysosome function and the release of mtDNA and other amphisomal content.

    • Jun Jin
    • Yunmei Mu
    • Jorg J. Goronzy
    Research
    Nature Aging
    Volume: 3, P: 600-616

  • For decades vitamin C’s primary function in bone has been attributed to its involvement in collagen synthesis. Here, the authors uncover that vitamin C’s central role in bone is to globally orchestrate osteogenesis via epigenetic mechanisms.

    • Roman Thaler
    • Farzaneh Khani
    • Andre J. van Wijnen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • In a mouse model of atherosclerosis, Childs and colleagues show that senescent cells inhibit the promigratory phenotype switching of vascular smooth muscle cells by secreting IGFBP3 and that senolysis promotes the repair of fibrous caps in advanced lesions.

    • Bennett G. Childs
    • Cheng Zhang
    • Jan M. van Deursen
    Research
    Nature Aging
    Volume: 1, P: 698-714

  • Senescent cells, which accumulate with ageing, are also involved in organ development and disease. Here, the authors examine the beneficial and detrimental effects of chronic and acute senescent cells in kidney formation, repair, disease and ageing and how these can be therapeutically modulated.

    • Ines Sturmlechner
    • Matej Durik
    • Jan M. van Deursen
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 77-89