Progerin, a truncated version of lamin A, causes Hutchinson–Gilford progeria syndrome characterized by premature aging and cardiovascular complications. Here the authors show that the most common progeria-causing mutation, LMNA c.1824C>T, is a somatic mutation in arteries from patients with chronic kidney disease, and that clonal propagation of the mutation in the vascular wall results in vascular aging phenotypes in mice.
- Gwladys Revêchon
- Anna Witasp
- Maria Eriksson
