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Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors

The GluA3 homomer substantially diverges from other AMPA-type glutamate receptors.

Aditya Pokharna
Imogen Stockwell
Ingo H. Greger
ResearchOpen Access01 Jul 2025
Nature

Volume: 645, P: 535-543
Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization

Combining patch-clamp electrophysiology, molecular dynamics simulations, cryo-electron microscopy and imaging of neuronal synapses, the authors reveal how AMPA glutamate receptors are regulated by protons that are released from synaptic vesicles during signal transmission.

Josip Ivica
Nejc Kejzar
Ingo H. Greger
ResearchOpen Access13 Aug 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1601-1613
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

AMPA receptors associated with TARP subunits enable the development of selective AMPA receptor drugs. Here, the authors provide cryo-EM structures of receptors bound to three TARP-γ8 selective drugs, and reveal bifunctionality of one ligand.

Danyang Zhang
Remigijus Lape
Ingo H. Greger
ResearchOpen Access25 Mar 2023
Nature Communications

Volume: 14, P: 1-13
Gating and modulation of a hetero-octameric AMPA glutamate receptor

Analyses of AMPA receptor–auxiliary subunit complexes provide insights into the gating and modulation of the AMPA receptor by TARP-γ8 and CNIH2.

Danyang Zhang
Jake F. Watson
Ingo H. Greger
Research02 Jun 2021
Nature

Volume: 594, P: 454-458
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor

Calcium-permeable GluA1 AMPA glutamate receptors are structurally and functionally distinct from the prototypical GluA2-containing AMPA receptors, impacting their role in signal transmission, synaptic plasticity and learning.

Danyang Zhang
Josip Ivica
Ingo H. Greger
ResearchOpen Access13 Sept 2023
Nature

Volume: 621, P: 877-882
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor

AMPA glutamate receptors, mediate the majority of excitatory signaling in the brain. Here the authors show how the auxiliary subunit TARP-γ8 shapes gating kinetics, ion conductance and rectification properties of the heteromeric GluA1/2 AMPA receptor.

Beatriz Herguedas
Bianka K. Kohegyi
Ingo H. Greger
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-12
AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions

Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.

Jake F. Watson
Alexandra Pinggera
Ingo H. Greger
ResearchOpen Access23 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Gilean McVean and colleagues report the results of a large-scale clinical genome sequencing project spanning a broad spectrum of disorders. They identify factors influencing successful genetic diagnosis and highlight the challenges of interpreting findings for genetically heterogeneous disorders.

Jenny C Taylor
Hilary C Martin
Gilean McVean
Research18 May 2015
Nature Genetics

Volume: 47, P: 717-726
Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains

Rajab et al. study the dynamics of closure of ligand binding domains (LBD) of the three major ionotropic glutamate receptor subtypes. They find pronounced sub-millisecond fluctuations in the apo state of LBDs from all three sub-types and reveal a pathway of allosteric communication in LBD dynamics across the dimerization interface

Suhaila Rajab
Leah Bismin
Hannes Neuweiler
ResearchOpen Access09 Sept 2021
Communications Biology

Volume: 4, P: 1-11
IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly

Javier García-Nafría
Jake F. Watson
Ingo H. Greger
ResearchOpen Access06 Jun 2016
Scientific Reports

Volume: 6, P: 1-12

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Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors

Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

Gating and modulation of a hetero-octameric AMPA glutamate receptor

Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor

Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor

AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains

IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly

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