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Showing 1–4 of 4 results
Advanced filters: Author: Ingunn Jermstad Clear advanced filters

  • Mammalian oocytes and embryos undergo major epigenetic changes. Here, genome-wide mapping of the histone variant H2A.Z across mouse oogenesis and early embryogenesis reveals distinct maternal, embryonic and persistent enrichment patterns, linking histone variant dynamics to epigenetic inheritance, repeats and developmental reprogramming.

    • Madeleine Fosslie
    • Erkut Ilaslan
    • Mads Lerdrup
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • Here the authors apply low-input methyl RNA immunoprecipitation and sequencing to map the N6-methyladenosine landscape during mouse oocyte and early embryo development. They show that RNAs derived from retrotransposons are often N6-methyladenosine marked and so are many genes important for the maternal-to-zygotic transition.

    • Yunhao Wang
    • Yanjiao Li
    • Kin Fai Au
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 703-709

  • Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

    • John Arne Dahl
    • Inkyung Jung
    • Arne Klungland
    Research
    Nature
    Volume: 537, P: 548-552