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Passive induction of experimental allergic encephalomyelitis

Ingunn M Stromnes
Joan M Goverman
Protocols22 Nov 2006
Nature Protocols

Volume: 1, P: 1952-1960
Germline T cell receptor exchange results in physiological T cell development and function

The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which uncovers that the natural genomic context for TCRs can enhance the antigen sensitivity of lower affinity TCRs and enables the physiologic range of antigen-TCR interaction and a gene dosage dependent mechanism of central tolerance.

Meagan R. Rollins
Jackson F. Raynor
Ingunn M. Stromnes
ResearchOpen Access01 Feb 2023
Nature Communications

Volume: 14, P: 1-19
Differential regulation of central nervous system autoimmunity by T_H1 and T_H17 cells

Ingunn M Stromnes
Lauren M Cerretti
Joan M Goverman
Research17 Feb 2008
Nature Medicine

Volume: 14, P: 337-342
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis

Patterson, Firulyova, et al. report that TREM2 is a key regulator of foamy macrophage differentiation. Myeloid-specific deletion of Trem2 caused increased macrophage susceptibility to cholesterol-mediated toxicity and cell death and significantly attenuated atherosclerotic plaque progression in mice.

Michael T. Patterson
Maria M. Firulyova
Jesse W. Williams
ResearchOpen Access30 Oct 2023
Nature Cardiovascular Research

Volume: 2, P: 1015-1031
An aged immune system drives senescence and ageing of solid organs

An aged, senescent immune system has a causal role in driving systemic ageing, and the targeting of senescent immune cells with senolytic drugs has the potential to suppress morbidities associated with old age.

Matthew J. Yousefzadeh
Rafael R. Flores
Laura J. Niedernhofer
Research12 May 2021
Nature

Volume: 594, P: 100-105
Osteopontin-induced survival of T cells

Relapses and exacerbation of clinical symptoms are hallmarks of debilitating autoimmune diseases like multiple sclerosis. Osteopontin-induced survival of autoreactive T cells may be one mechanism underlying the clinical progression of autoimmune disease.

Ingunn M Stromnes
Joan M Goverman
News & Views01 Jan 2007
Nature Immunology

Volume: 8, P: 19-20
CD8⁺ T cells maintain tolerance to myelin basic protein by 'epitope theft'

Antoine Perchellet
Ingunn Stromnes
Joan Goverman
Research16 May 2004
Nature Immunology

Volume: 5, P: 606-614
Chemotherapy brings virtual memory T cells into reality for cancer therapy

Zoe C. Schmiechen
Adam L. Burrack
Ingunn M. Stromnes
Comments & Opinion03 Jul 2020
Cellular & Molecular Immunology

Volume: 18, P: 1339-1340
Active induction of experimental allergic encephalomyelitis

Ingunn M Stromnes
Joan M Goverman
Protocols16 Nov 2006
Nature Protocols

Volume: 1, P: 1810-1819

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