Nature Search

DeMBA: a developmental atlas for navigating the mouse brain in space and time

Current developmental brain atlases are limited in the number of stages they represent. Here authors generate the Developmental Mouse Brain Atlas, a 4D atlas representing every postnatal day from 4 to 56.

Harry Carey
Heidi Kleven
Ingvild E. Bjerke
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-13
DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas

Navigating the complex structure of the brain poses a challenge to neuroscientists. Here, the authors have trained an AI (DeepSlice) that can automatically register brain images with speed and accuracy, thus simplifying this process.

Harry Carey
Michael Pegios
Simon McMullan
ResearchOpen Access21 Sept 2023
Nature Communications

Volume: 14, P: 1-11
Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration

An updated version of the Waxholm Space atlas of the rat brain includes more detailed annotations of several brain regions, including the cortex, striatopallidal region, midbrain and thalamus, expanding the previous version with 112 new and 57 revised structures.

Heidi Kleven
Ingvild E. Bjerke
Trygve B. Leergaard
ResearchOpen Access02 Oct 2023
Nature Methods

Volume: 20, P: 1822-1829
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model

QUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.

Brianna Gurdon
Sharon C. Yates
Catherine C. Kaczorowski
ResearchOpen Access20 May 2024
Communications Biology

Volume: 7, P: 1-16
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Database of literature derived cellular measurements from the murine basal ganglia

Ingvild E. Bjerke
Maja A. Puchades
Trygve B. Leergaard
ResearchOpen Access06 Jul 2020
Scientific Data

Volume: 7, P: 1-14

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