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Showing 1–8 of 8 results
Advanced filters: Author: Injin Bang Clear advanced filters

  • Here the authors applied cryogenic time-resolved electron microscopy with rapid UV photolysis of a caged substrate to elucidate the catalytic mechanism of lipid-sugar transfer within the bacterial membrane by the glycosyltransferase GtrB.

    • Ryan T. Morgan
    • Stefano Motta
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Using directed evolution and structure-guided design, human synthetic antibodies selective to HER2 point mutants were developed. The use of the antibodies as T cell engagers killed HER2-mutant cancer cells while sparing HER2-wild-type normal cells.

    • Injin Bang
    • Takamitsu Hattori
    • Shohei Koide
    Research
    Nature Chemical Biology
    Volume: 21, P: 706-715

  • The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention. Here, the authors show that, unlike in other neuropeptides, both the N-terminal and the C-terminal regions of NPY interact with the NPY receptor 1.

    • Chaehee Park
    • Jinuk Kim
    • Hee-Jung Choi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The low-density lipoprotein receptor-related protein 6 (LRP6) is a co-receptor of the β-catenin-dependent Wnt signaling pathway and interacts with the Wnt inhibitor sclerostin (SOST). Here the authors present the crystal structure of SOST in complex with the LRP6 E1E2 ectodomain construct, which reveals that the SOST C-terminus binds to the LRP6 E2 domain, and further validate this binding site with in vitro and in vivo experiments.

    • Jinuk Kim
    • Wonhee Han
    • Hee-Jung Choi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.

    • Seung-Bum Ko
    • Emiko Mihara
    • Hee-Jung Choi
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-12