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Showing 1–7 of 7 results
Advanced filters: Author: Inmaculada Tasset Clear advanced filters

  • Khawaja et al. show sex-specific differences in neuronal-activity regulation by chaperone-mediated autophagy and that loss of chaperone-mediated autophagy leads to defective neuronal physiology and increased seizure susceptibility, linking chaperone-mediated autophagy to neuronal excitability.

    • Rabia R. Khawaja
    • Ernesto Griego
    • Ana Maria Cuervo
    Research
    Nature Cell Biology
    Volume: 27, P: 1688-1707

  • This study shows that Parkinson's disease–associated mutant forms of leucine-rich repeat kinase 2 (LRRK2) impair chaperone-mediated autophagy in neurons, thereby reducing degradation of α-synuclein by this pathway and contributing to the accumulation of this protein observed in brain tissue from patients with Parkinson's disease.

    • Samantha J Orenstein
    • Sheng-Han Kuo
    • Ana Maria Cuervo
    Research
    Nature Neuroscience
    Volume: 16, P: 394-406

  • Nutrient status in the cell regulates autophagy via mTORC1 activity. Here, the authors show that the ubiquitous G protein subunit Gαq contributes to nutrient sensing by promoting formation of an mTOR-p62-Raptor complex in replete conditions, modulating autophagy.

    • Sofía Cabezudo
    • Maria Sanz-Flores
    • Catalina Ribas
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Using single-cell imaging of a fluorescent chaperone-mediated autophagy (CMA) reporter and RNA sequencing data, the authors present a resource on basal CMA activity across organs, cell types and sexes in young and old mice, offering a comprehensive overview of changes in this proteostatic mechanism in the context of aging.

    • Rabia R. Khawaja
    • Adrián Martín-Segura
    • Ana Maria Cuervo
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 691-708