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Showing 1–6 of 6 results
Advanced filters: Author: Ioannis Prassas Clear advanced filters

  • Members of the family of kallikrein (KLK)-related proteases are found in various tissues — including the airway, prostate and brain — and have a wide range of functions. The authors describe the roles of KLKs in health and disease, and highlight the small-molecule, peptide-based, protein-based, antibody-based and immunotherapeutic strategies that are being used to target KLKs in certain diseases.

    • Ioannis Prassas
    • Azza Eissa
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 183-202

  • B cells are playing an active role in shaping the tumour immune microenvironment and the anti-tumour immune response in melanomas. Here authors show that intra-tumoral B cells are aberrantly activated and produce antibodies that are potentially autoreactive.

    • Silvia Crescioli
    • Isabel Correa
    • Sophia N. Karagiannis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Cardiac glycosides, a diverse family of naturally derived compounds that inhibit Na+/K+-ATPase, have been used for many years for the treatment of heart failure and atrial arrhythmia. This article discusses recent evidence highlighting additional signal transduction roles for Na+/K+-ATPase, and associated potential new therapeutic appplications for glycoside-based drugs in a range of diseases — most notably cancer, for which the first generation of such agents are currently in clinical trials.

    • Ioannis Prassas
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 926-935

  • Proteomic and biochemical studies on cervical-vaginal fluid (CVF) have revealed that it contains several members of the tissue kallikrein-related peptidase (KLK) family. The roles of KLKs in the lower female reproductive system are not fully understood. In this Review, Muytjens and colleagues discuss the putative roles of KLKs in vaginal fluid and how increased understanding of their function could result in new diagnostic and therapeutic modalities.

    • Carla M. J. Muytjens
    • Stella K. Vasiliou
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Urology
    Volume: 13, P: 596-607

    • Vathany Kulasingam
    • Ioannis Prassas
    • Eleftherios P. Diamandis
    CorrespondenceOpen Access
    npj Precision Oncology
    Volume: 1, P: 1-4