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Nature Biomedical Engineering (1)

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Computational optimization of antibody humanness and stability by systematic energy-based ranking

A computational method for the systematic grafting of animal complementarity-determining regions onto thousands of human frameworks allows for the design of humanized versions of antibodies with improved stability.

Ariel Tennenhouse
Lev Khmelnitsky
Sarel J. Fleishman
Research07 Aug 2023
Nature Biomedical Engineering

Volume: 8, P: 30-44

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Computational optimization of antibody humanness and stability by systematic energy-based ranking

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