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  • Aneuploid cancer cell lines show increased dependence on the spindle assembly complex (SAC); initially they are resistant to SAC perturbations, but over time they accumulate chromosomal aberrations that impair their fitness.

    • Yael Cohen-Sharir
    • James M. McFarland
    • Uri Ben-David
    Research
    Nature
    Volume: 590, P: 486-491