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Showing 1–8 of 8 results
Advanced filters: Author: Irina Shchukina Clear advanced filters

  • A study finds T cells in areas of tau, not amyloid, pathology in Alzheimer’s disease brain and mouse models, with their presence correlating with neuronal loss and their depletion, or that of microglia, preventing neurodegeneration and cognitive decline.

    • Xiaoying Chen
    • Maria Firulyova
    • David M. Holtzman
    Research
    Nature
    Volume: 615, P: 668-677

  • The ketogenic diet is a low-carbohydrate, high-fat diet that forces a metabolic switch towards fatty acid oxidation. Here, Goldberg et al. show that a ketogenic diet initially improves metabolic health and expands adipose tissue γδ T cells that are important for glycaemic control during obesity.

    • Emily L. Goldberg
    • Irina Shchukina
    • Vishwa Deep Dixit
    Research
    Nature Metabolism
    Volume: 2, P: 50-61

  • Studying ageing at the single-cell level has provided insight into the changes that occur systemically and in tissues as we age. For example, we now have a greater appreciation of the heterogeneity and dynamic nature of immune cell ageing and of the impact of age-associated tissue remodelling on the immune system, together contributing to increased vulnerability to some diseases.

    • Denis A. Mogilenko
    • Irina Shchukina
    • Maxim N. Artyomov
    Reviews
    Nature Reviews Immunology
    Volume: 22, P: 484-498

  • Koenig et al. present integrated single-cell and single-nucleus RNA-sequencing data of cardiac samples obtained from 27 healthy donors and 18 individuals with dilated cardiomyopathy. This extensive resource provides insights on cell composition and gene expression changes driven by the disease status, sex or age of the patients.

    • Andrew L. Koenig
    • Irina Shchukina
    • Kory J. Lavine
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 263-280