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Showing 1–4 of 4 results
Advanced filters: Author: Iris Z. Uras Clear advanced filters

  • A chemical-genetic study predicts mechanisms of resistance to PI3K inhibitors. Activation of NOTCH signaling, which leads to c-MYC expression, can overcome cancer cell dependency on PI3K signaling for growth. NOTCH and PI3K have not previously been linked in breast cancer.

    • Markus K Muellner
    • Iris Z Uras
    • Sebastian M B Nijman
    Research
    Nature Chemical Biology
    Volume: 7, P: 787-793

  • Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling induces apoptosis in these cells.

    • Ingeborg Menzl
    • Tinghu Zhang
    • Veronika Sexl
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

    • Michal Smida
    • Ferran Fece de la Cruz
    • Sebastian M. B. Nijman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13