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Showing 1–5 of 5 results

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Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

Towia A. Libermann
Harris R. Nusbaum
Joseph Schlessinger
Research10 Jan 1985
Nature

Volume: 313, P: 144-147
Structure of a heparin-linked biologically active dimer of fibroblast growth factor

Anna D. DiGabriele
Irit Lax
Wayne A. Hendrickson
Research25 Jun 1998
Nature

Volume: 393, P: 812-817
Mechanism for the activation of the anaplastic lymphoma kinase receptor

Cryo-electron microscopy, nuclear magnetic resonance and X-ray crystallography are used to provide structural and mechanistic details of the activation of anaplastic lymphoma kinase by the ligands ALKAL1 and ALKAL2.

Andrey V. Reshetnyak
Paolo Rossi
Charalampos G. Kalodimos
Research24 Nov 2021
Nature

Volume: 600, P: 153-157
Structural basis for ligand reception by anaplastic lymphoma kinase

Analysis of crystal structures of anaplastic lymphoma kinase elucidate the mechanism by which ligand binding and the glycine-rich domain regulate its activity.

Tongqing Li
Steven E. Stayrook
Daryl E. Klein
Research24 Nov 2021
Nature

Volume: 600, P: 148-152
Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

Crystal structures of free and ligand-bound β-klotho reveal that it acts as a primary receptor for FGF21, and demonstrate how a sugar-cutting enzyme has evolved to become a receptor for hormones that regulate metabolic processes.

Sangwon Lee
Jungyuen Choi
Joseph Schlessinger
Research17 Jan 2018
Nature

Volume: 553, P: 501-505