Dendritic cells (DCs) initiate distinct arms of immunity in response to different classes of pathogens. Here Gringhuis et al. show that DCs produce IL-27 upon sensing fucose-containing pathogen ligands via DC-SIGN, promoting follicular T helper cell differentiation and antibody production.
- Sonja I. Gringhuis
- Tanja M. Kaptein
- Teunis B. H. Geijtenbeek
