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Showing 1–3 of 3 results
Advanced filters: Author: Isaac Fianu Clear advanced filters

  • Cryo-electron microscopy structures of the human Integrator complex in three different functional states shed light on how Integrator terminates RNA polymerase II (Pol II) transcription by disengaging Pol II from the DNA template.

    • Isaac Fianu
    • Moritz Ochmann
    • Patrick Cramer
    ResearchOpen Access
    Nature
    Volume: 629, P: 219-227

  • RNA polymerase II needs to be imported into the nucleus to perform transcription. Fianu et al. show that RPAP2 binds to Pol II and enters the nucleus with it, before releasing it to perform transcription and returning to the cytoplasm.

    • Isaac Fianu
    • Christian Dienemann
    • Patrick Cramer
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-7

  • Here the authors visualize the workings of ELOF1 in transcription-coupled DNA repair, showing that ELOF1 repositions repair factors on the surface of DNA damage-stalled RNA polymerase II to facilitate its ubiquitylation by the CRL4CSA E3 ligase and inactivation by UVSSA.

    • Goran Kokic
    • George Yakoub
    • Martijn S. Luijsterburg
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 536-547