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Showing 1–3 of 3 results

Advanced filters: Author: Isabel Plasencia-Fernandez Clear advanced filters

Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

Inhibition in spinal nociceptive pathways is weaker and more labile in lamina I —where thermal input is primarily processed— than in lamina II that encodes predominantly high threshold mechanical input. This explains why noxious thermal input makes spinal circuits prone to catastrophic sensitization.

Francesco Ferrini
Jimena Perez-Sanchez
Yves De Koninck
ResearchOpen Access07 Aug 2020
Nature Communications

Volume: 11, P: 1-18
Enhancing neuronal chloride extrusion rescues α2/α3 GABA_A-mediated analgesia in neuropathic pain

Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABA_A receptor in a neuropathic pain model, inhibition eventually fails due to KCC2 hypofunction.

Louis-Etienne Lorenzo
Antoine G. Godin
Yves De Koninck
ResearchOpen Access13 Feb 2020
Nature Communications

Volume: 11, P: 1-23
Reply to The small molecule CLP257 does not modify activity of the K⁺–Cl⁻ co-transporter KCC2 but does potentiate GABA_A receptor activity

Martin Gagnon
Marc J Bergeron
Yves De Koninck
Correspondence07 Dec 2017
Nature Medicine

Volume: 23, P: 1396-1398

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