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Showing 1–3 of 3 results
Advanced filters: Author: Isabelle Damei Clear advanced filters

  • Features of the stroma and immune infiltrate in patients with invasive lobular breast carcinoma (ILC) have been associated with poor prognosis. Here the authors report that E-cadherin loss in ILC cancer cells influences cancer associated fibroblast differentiation and spatial organization of tumor-infiltrating lymphocytes, resulting in immune escape and poor prognosis.

    • Lounes Djerroudi
    • Rana Mhaidly
    • Fatima Mechta-Grigoriou
    ResearchOpen Access
    Nature Communications
    P: 1-23

  • While the involvement of CD8 tissue-resident memory T (TRM) cells in the response to ICB therapy has been reported, less is known about the relevance of CD4 TRM cells. Here, using mouse cancer models and human melanoma samples and NSCLC dataset, the authors show that CD49a+ CD4 TRM cells often accumulate in pre-treatment tumours, and their presence correlates with a favourable response to anti-CTLA-4 therapy.

    • Isabelle Damei
    • Aziza Caidi
    • Fathia Mami-Chouaib
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Response to PD-1 checkpoint blockade is unpredictable in lung cancer patients. Here authors show in human lung and mouse tumour models that low or absent αV integrin expression leads to better tumour growth control by anti-PD-1 via reduced TGF-β activation and hence increased infiltration of anti-tumour CD8+ T cells.

    • Ines Malenica
    • Julien Adam
    • Fathia Mami-Chouaib
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16