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Showing 1–3 of 3 results
Advanced filters: Author: Isabelle Rouvet Clear advanced filters

  • The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.

    • Xiaona Sun
    • Ting Liu
    • Junjie Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • SOCS1 is a potent suppressor of JAK-STAT signalling responses to IFNγ and γ-chain cytokines and thereby limits inflammation. Here the authors identify and characterize heterozygous SOCS1 mutations in 10 patients from 5 unrelated families with autoimmune diseases.

    • Jérôme Hadjadj
    • Carla Noemi Castro
    • Frédéric Rieux-Laucat
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Dispersed lipid self-assembly can form various types of particles, including cubosomes, which are useful for drug delivery. Here, Demurtas et al. visualize their three-dimensional structure, showing two continuous water channels separated by lipid bilayers and the mechanism of particle stabilization.

    • Davide Demurtas
    • Paul Guichard
    • Laurent Sagalowicz
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8