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Showing 1–14 of 14 results
Advanced filters: Author: Isak S. Pretorius Clear advanced filters

  • The Sc2.0 project involved synthesis and debugging of 16 chromosomes, and a tRNA neochromosome. Here the authors descript the SynXVI project, accompanied by an analysis of how similar projects could operate with hindsight and newly available technologies, and lessons learned from Sc2.0.

    • Hugh D. Goold
    • Heinrich Kroukamp
    • Isak S. Pretorius
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. This Comment summarizes the design- and construction-related defects revealed during the construction of 16 synthetic chromosomes, and the solutions applied, drawing out the key biological and technical insights that will inform future genome-scale engineering.

    • Paige E. Erpf
    • Felix Meier
    • Isak S. Pretorius
    Comments & Opinion
    Nature Biotechnology
    Volume: 43, P: 1911-1918

  • The Sc2.0 consortia is reengineering the yeast genome. To expand the Sc2.0 genetic repertoire, the authors build a neo-chromosome comprising variable loci from diverse yeast isolates, providing phenotypic plasticity for use in synthetic backgrounds.

    • Dariusz R. Kutyna
    • Cristobal A. Onetto
    • Anthony R. Borneman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • A Global Forum on Synthetic Biology is needed to engage policymakers with practitioners across borders at the highest level. The international community needs a global confidence-building measure focused on discussing policy futures for the age of engineering biology.

    • Thomas A. Dixon
    • Paul S. Freemont
    • Isak S. Pretorius
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 13, P: 1-5

  • Technologies from synthetic biology can be applied to traditional practices in winemaking. Possibilities beyond natural microbial communities exist to improve predictive capabilities for the winemaker vintage to vintage, and introduce new characteristics to wine.

    • Roy S. K. Walker
    • Isak S. Pretorius
    Reviews
    Nature Food
    Volume: 3, P: 249-254

  • The nexus of biotechnology, information technology, nanotechnology and engineering is at the heart of innovation. Here the authors explore breakthroughs in integrating chip technology and bioinformational processing for this emerging interface of bio-inspired engineering and engineering-enabled biology.

    • Isak S. Pretorius
    • Thomas A. Dixon
    • Daniel L. Johnson
    ReviewsOpen Access
    Nature Communications
    Volume: 16, P: 1-8

  • Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.

    • Nathan Hillson
    • Mark Caddick
    • Paul S. Freemont
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 10, P: 1-4

  • Naturally evolved genomes tend to be unnecessarily large and redundant, and are not optimised for biotechnological or research applications. In this review, the authors explore genome minimization and re-functionalisation approaches, and discuss their potential for industrial applications.

    • Xin Xu
    • Felix Meier
    • Thomas C. Williams
    ReviewsOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Engineering biology is a dynamic field that uses gene editing, synthesis, assembly, and engineering to design new or modified biological systems. Here the authors discuss the policy considerations and interventions needed to support a role for engineering biology in climate change mitigation.

    • Jonathan Symons
    • Thomas A. Dixon
    • Isak S. Pretorius
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Long-duration human space travel creates challenges for maintaining healthy diets. Here the authors discuss using synthetic biology approaches to modify yeast into an optimal, and enjoyable, food production platform.

    • Briardo Llorente
    • Thomas C. Williams
    • Ian T. Paulsen
    ReviewsOpen Access
    Nature Communications
    Volume: 13, P: 1-7

  • Synthetic biology engineering principles enable two-way communication between living and inanimate substrates. Here the authors consider the development of this bio-informational exchange and propose cyber-physical architectures and applications.

    • Thomas A. Dixon
    • Thomas C. Williams
    • Isak S. Pretorius
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Synthetic metagenomics could potentially unravel the complexities of microbial ecosystems by revealing the simplicity of microbial communities captured in a single cell. Conceptionally, a yeast cell carrying a representative synthetic metagenome could uncover the complexity of multi-species interactions, illustrated here with wine ferments.

    • Ignacio Belda
    • Thomas C. Williams
    • Isak S. Pretorius
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 12, P: 1-8