Marina Shenkman et al. show that the ERAD mannosidases EDEM1 and EDEM2 have bona fide mannosidase activity in vitro. The activity of these enzymes is substantially faster when their glycoprotein substrates are in the unfolded state, suggesting a mechanism for efficient ERAD targeting of unfolded or misfolded glycoproteins.
- Marina Shenkman
- Efrat Ron
- Gerardo Z. Lederkremer
