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ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

Cells must be able to sense and respond to changes in osmotic pressure, which can be lethal. Here, Naguro and colleagues reveal a role for the protein kinase ASK3 in sensing osmotic stress in the mouse kidney and show that ASK3 contributes to the regulation of blood pressure.

Isao Naguro
Tsuyoshi Umeda
Hidenori Ichijo
Research18 Dec 2012
Nature Communications

Volume: 3, P: 1-11
Functional cooperation between ASK1 and p21^Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Carlo De Blasio
Nagendra Verma
Claudio Talora
ResearchOpen Access12 Apr 2021
Cell Death Discovery

Volume: 7, P: 1-8
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptotic gene expression.

Taku Ito-Kureha
Takahisa Miyao
Tadashi Yamamoto
ResearchOpen Access02 Dec 2020
Nature Communications

Volume: 11, P: 1-12
ASK1 signalling regulates brown and beige adipocyte function

The protein kinase ASK1 has been linked to cellular stress responses. Here the authors show that ASK1 also regulates gene expression and activity of beige and brown adipocytes, and demonstrate adipocyte ASK1 has a physiological role in regulating thermogenesis in mice.

Kazuki Hattori
Isao Naguro
Hidenori Ichijo
ResearchOpen Access05 Apr 2016
Nature Communications

Volume: 7, P: 1-10
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.

Kengo Watanabe
Kazuhiro Morishita
Hidenori Ichijo
ResearchOpen Access01 Mar 2021
Nature Communications

Volume: 12, P: 1-15
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model.

Naomi Tsuburaya
Kengo Homma
Hidenori Ichijo
ResearchOpen Access10 Jul 2018
Nature Communications

Volume: 9, P: 1-12
HES1 potentiates high salt stress response as an enhancer of NFAT5-DNA binding

HES1, a well-known transcriptional repressor, promotes NFAT5-dependent transcription in the context of a high salinity/hyperosmotic environment and contributes to high salt stress response.

Hiroki Ryuno
Yusuke Hanafusa
Hidenori Ichijo
ResearchOpen Access09 Oct 2024
Communications Biology

Volume: 7, P: 1-15
ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

Saki Takayanagi
Kengo Watanabe
Hidenori Ichijo
ResearchOpen Access10 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
NAMPT-dependent NAD⁺ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress

Takuto Nishida
Isao Naguro
Hidenori Ichijo
ResearchOpen Access11 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-11
ASK1 promotes uterine inflammation leading to pathological preterm birth

Midori Yoshikawa
Takayuki Iriyama
Tomoyuki Fujii
ResearchOpen Access05 Feb 2020
Scientific Reports

Volume: 10, P: 1-11
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway

Junichi Maruyama
Yumie Kobayashi
Isao Naguro
ResearchOpen Access06 Jan 2016
Scientific Reports

Volume: 6, P: 1-14
ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y₁₂ in platelets

Miki Kamiyama
Toshiaki Shirai
Hidenori Ichijo
Research28 Jul 2017
Cell Death & Differentiation

Volume: 24, P: 2066-2076

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