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Showing 1–2 of 2 results
Advanced filters: Author: Islam Baiev Clear advanced filters

  • It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations than single tissue samples.

    • Bernard Pereira
    • Christopher T. Chen
    • Dejan Juric
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Patients with BRAFV600E-mutated colorectal cancer have encouraging overall response rates to inhibition of PD-1, BRAF and MEK, with translational analyses suggesting that induction of tumor-intrinsic programs and immune programs contributes to improved outcomes via MAPK inhibition.

    • Jun Tian
    • Jonathan H. Chen
    • Ryan B. Corcoran
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 458-466