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Advanced filters: Author: Istvan Enyedy Clear advanced filters

Human PLD structures enable drug design and characterization of isoenzyme selectivity

Crystal structures of phospholipase hPLD1 and hPLD2 catalytic domains and an analysis of the binding modes of dual and isoform-selective inhibitors define mechanisms of PLD regulation and catalytic activity.

Claire M. Metrick
Emily A. Peterson
Jayanth V. Chodaparambil
Research10 Feb 2020
Nature Chemical Biology

Volume: 16, P: 391-399
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Edward Y. S. Lin
Laura F. Silvian
Kevin M. Guckian
ResearchOpen Access07 Sept 2018
Scientific Reports

Volume: 8, P: 1-10

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Human PLD structures enable drug design and characterization of isoenzyme selectivity

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

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