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Showing 1–29 of 29 results
Advanced filters: Author: Ivan K. Schuller Clear advanced filters
  • Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

    • Flavia W. de Faria
    • Nicole C. Riedel
    • Kornelius Kerl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Previous work has shown that electronic and structural transitions in VO2 can be decoupled by realizing an electronic transition within a monoclinic phase. Here, the authors extend this to the rutile phase by demonstrating a photodoping-driven transition from an insulating to a metallic rutile phase.

    • Shaobo Cheng
    • Henry Navarro
    • Yimei Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7
  • AI-enabled diagnostic applications in healthcare can be powerful, but study design is very important to avoid subtle issues of bias in the dataset and evaluation. Coppock et al. demonstrate how an AI-based classifier for diagnosing SARS-Cov-2 infection from audio recordings can seem to make predictions with high accuracy but shows much lower performance after taking into account confounders, providing insights in study design and replicability in AI-based audio analysis.

    • Harry Coppock
    • George Nicholson
    • Chris Holmes
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 6, P: 229-242
  • Thermal neuristors based on VO2 have been suggested for neuromorphic computing. Here, authors show that neuristor arrays exhibit long-range order without criticality, revealing that it is not necessary for effective information processing in such systems, and challenging the critical brain hypothesis.

    • Yuan-Hang Zhang
    • Chesson Sipling
    • Massimiliano Di Ventra
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8
  • Telomeres are endogenous cellular targets of DNA ADP-ribosylation (DNA-ADPr). TARG1-regulated DNA-ADPr is coupled to lagging telomere DNA strand synthesis, and persistent DNA-ADPr, due to TARG1 deficiency, leads to telomere shortening and fragility.

    • Anne R. Wondisford
    • Junyeop Lee
    • Roderick J. O’Sullivan
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 791-800
  • Filamentary RRAM technologies suffer from variations and noise, leading to computational accuracy loss, and increased energy consumption. Park et al. created a trilayer metal-oxide bulk switching RRAM technology without filament formation and showed edge computing for an autonomous navigation task.

    • Jaeseoung Park
    • Ashwani Kumar
    • Duygu Kuzum
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • Structural and mechanistic data of the ADP-ribosyltransferase DarT demonstrate the role of ADP-ribosylation of DNA by this enzyme in generating toxicity and regulating cellular signalling processes in bacteria.

    • Marion Schuller
    • Rachel E. Butler
    • Ivan Ahel
    Research
    Nature
    Volume: 596, P: 597-602
  • A near-field optical microscopy study provides nanoscale insight into an insulator-to-metal transition and the interplay with a neighbouring structural phase transition in a prototypical correlated electron material.

    • A. S. McLeod
    • E. van Heumen
    • D. N. Basov
    Research
    Nature Physics
    Volume: 13, P: 80-86
  • Fragment-based drug discovery employs screening of small polar compounds typically exhibiting low affinity towards protein targets. Here, the authors combine the use of protein-based binding pharmacophores with the theory of protein hotspots to develop a design protocol for fragment libraries, called SpotXplorer, and validate their approach on common and emerging drug targets.

    • Dávid Bajusz
    • Warren S. Wade
    • György M. Keserű
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Despite intensive research on the electrically driven insulator-to-metal transition, this phenomenon is not well understood. Using quasi 1D nanowires of two Mott insulators, the authors reveal the central role of defects in enabling a non-thermal doping driven insulator-to metal transition.

    • Yoav Kalcheim
    • Alberto Camjayi
    • Ivan K. Schuller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9
  • Resistive switching usually occurs by the formation of conducting filaments in the direction of current flow. Here the authors study an intriguing type of volatile metal-to-insulator resistive switching in (La,Sr)MnO3, which occurs by the formation of an insulating barrier perpendicular to the current.

    • Pavel Salev
    • Lorenzo Fratino
    • Ivan K. Schuller
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-7
  • The storage density of computer hard drives has increased to the point that magnetic recording media is cheaper than paper. Yet there are limits to this technology. As they decrease in size, magnetic 'bits' become thermally unstable, providing a challenge to further miniaturization.

    • Johannes Eisenmenger
    • Ivan K. Schuller
    News & Views
    Nature Materials
    Volume: 2, P: 437-438
  • Mott materials feature scale-less relaxation dynamics after the insulator-to-metal transition that make its electric triggering dependent on recent switching events.

    • Javier del Valle
    • Pavel Salev
    • Ivan K. Schuller
    Research
    Nature
    Volume: 569, P: 388-392
  • Research with thin films of material has unveiled physical phenomena that are not apparent in the bulk matter. Now, in the field of superconductivity, come indications that when films of a particular copper oxide are grown under compressive strain, their transition (critical) temperature as much as doubles. Increases in transition temperature have been achieved using pressure, but they have not been nearly as large as that described in the new work.

    • Ivan K. Schuller
    News & Views
    Nature
    Volume: 394, P: 419-421