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Showing 1–3 of 3 results
Advanced filters: Author: Ivan Mikicic Clear advanced filters

  • Whether actin and associated molecules have roles in the nucleus is an active area of study. Here Shi et al. report a nuclear function of the actin-based motor myosin VI in protecting stalled replication forks from nuclease-mediated degradation.

    • Jie Shi
    • Kristine Hauschulte
    • Hans-Peter Wollscheid
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • MYC dissociation from active promoters alters its interactions with proteins involved in transcription termination and RNA processing, influencing DNA repair and thus, potentially, tumour cell growth.

    • Daniel Solvie
    • Apoorva Baluapuri
    • Martin Eilers
    Research
    Nature
    Volume: 612, P: 148-155

  • Transcription can pose a threat to genomic instability through the formation of R-loops, which are RNA–DNA hybrids with a displaced non-template DNA strand. Here the authors mapped the R-loop proximal proteome in human cells and identified a role of the tumor suppressor DDX41 in opposing R-loop and double strand DNA break accumulation in gene promoters.

    • Thorsten Mosler
    • Francesca Conte
    • Petra Beli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17