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Showing 1–6 of 6 results
Advanced filters: Author: Ivan S. Okhrimenko Clear advanced filters

  • S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and shedding light on inverse agonism in S1P receptors.

    • Elizaveta Lyapina
    • Egor Marin
    • Vadim Cherezov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Proteorhodopsins act as light-driven outward proton pumps mainly at neutral and alkaline pH, however, mirror proteorhodopsins are known to operate only at acidic pH. Here, the authors report the detailed structural and functional characterization of pH mirror proteorhodopsin SpaR as well as its diverse biological roles.

    • Ivan S. Okhrimenko
    • Kirill Kovalev
    • Valentin I. Gordeliy
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-16

  • Noble gases are known to interact with proteins and can be good anaesthetics in hyperbaric conditions. This study identifies argon and krypton binding sites on membrane proteins and proposes as a hypothesis that noble gases, by altering protein/lipid contacts, may affect protein function.

    • Igor Melnikov
    • Philipp Orekhov
    • Alexander Popov
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-12

  • Zabelskii et al. present a structural and functional analysis of the lightdriven proton pump LR (Mac) from the fungus Leptosphaeria maculans. Their findings indicate that the archaeal ancestry of eukaryotic type 1 rhodopsins, and that the archaeal host of the proto-mitochondrial endosymbiont was capable of light-driven proton pumping.

    • Dmitrii Zabelskii
    • Natalia Dmitrieva
    • Valentin Gordeliy
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12