Tumour profiling with next-generation sequencing is challenging due to the low amounts of diagnostic material in cytology samples that are obtained through non-invasive procedures. Here, the authors report on the optimization of this process across 4,871 cancer cytology samples profiled by MSK-IMPACT, with emphasis on the successful use of supernatant cell-free DNA.
- David Kim
- Chad M. Vanderbilt
- Maria E. Arcila
